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MONOTOPIC PHOSPHOGLYCOSYL TRANSFERASES SET SAIL

"Membrane association of monotopic phosphoglycosyl transferase underpins function" Ray, L.C.; Das, D.; Entova, S.; Lukose, V.; Lynch, A.J.; Imperiali, B.; Allen, K.N. Nature Chemical Biology 2018, 14, 538-541. doi: 10.1038/s41589-018-0054-z

 
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NUCLEOSIDES ON DEMAND

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“Facile Solid-Phase Synthesis and Assessment of Nucleoside Analogs as Inhibitors of Bacterial UDP-Sugar Processing Enzymes” Madec, A. G. M.; Schocker, N. S.; Sanchini, S.; Myratgeldiyev, G.; Das, D.; Imperiali, B.  ACS Chem Bio 2018, 10.1021/acschembio.8b00477..

PING PONG ANYONE?!

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"Analysis of a Dual Domain Phosphoglycosyl Transferase Reveals a Ping-Pong Mechanism with a Covalent Enzyme Intermediate", Das, D.; Kuzmic, P.; Imperiali, B. Proc. Natl. Acad. Sci. U.S.A. 2017, 114(27):7019-7024.  PMCID: PMC5502628.  

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SAME BUT DIFFERENT

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“Stereochemical Divergence of Polyprenol Phosphate Glycosyltransferases“ Eichler, J.; Imperiali, B. Trends Biochem. Sci2018, 43, 9-16.