2017

205. "Stereochemical Divergence of Polyprenol Phosphate Glycosyl Transferases" Eichler, J.; Imperiali, B. Trends in Biochemical Sciences, 2018, 43, 9-16.

204. "Bacterial Phosphoglycosyl Transferases: Initiators of Glycan Biosynthesis at the Membrane Interface" Lukose, V.; Walvoort, M. T. C.; Imperiali, B. Glycobiology. 2017, 27, 820-833.

203. "Chemoenzymatic Synthesis and Applications of Prokaryote-Specific UDP-Sugars", Zamora, C. Y.; Schocker, N. S.; Chang, M. M. Imperiali, B. Meth. Enzymol. 2017, 597, 145-186.

202. "Analysis of a Dual Domain Phosphoglycosyl Transferase Reveals a Ping-Pong Mechanism with a Covalent Enzyme Intermediate", Das, D.; Kuzmic, P.; Imperiali, B. Proc. Natl. Acad. Sci. U.S.A. 2017, 114, 7019-7024. PMCID: PMC5502628.

201. "Conformational Dynamics and Alignment Properties of Loop Lanthanide-Binding Tags (LBTs) Studied in Interleukin-1β", Schwalbe, H.; Barthelmes, D.; Barthelmes, K.; Schnorr, K.; Hendrik R. A. Jonker; B. B.; Allen, K. N.; Imperiali, B. J. Biomol. NMR, 2017, 68, 187-194.

200. “Targeting Bacillosamine Biosynthesis in Bacterial Pathogens: Development of Inhibitors to Bacterial Amino-Sugar Acetyl Transferase from Campylobacter jejuni“, De Schutter, J. W.; Morrison, J. P.; Morrison, M. J.; Ciulli, A.; Imperiali, B. J. Med. Chem. 2017, 60, 2099-2118. PMCID: PMC5506375.

2016

199. “Antibodies from Multiple Sclerosis Patients Preferentially Recognize Hyperglucosylated Adhesin of Non-Typeable Haemophilus influenzae“, Walvoort, M. T. C.; Testa, C.; Eilam, R.; Aharoni, R.; Nuti, F.; Rossi, G.; Real-Fernandez, R.; Lanzillo, R.; Morra, V. B.; Lolli, F.; Rovero, P.; Imperiali, B.; Papini, A-M. Scientific Reports, 2016, 6, 39430. PMCID: PMC5180199.

198. “Bacterial N-Glycosylation Efficiency is Dependent on the Structural Context of Target Sequons” Silverman, J. M.; Imperiali, B. J. Biol. Chem. 2016, 291, 22001-22010. PMCID: PMC5063983.

197. “A Rapid and Efficient Luminescence-based Method for Assaying Phosphoglycosyltransferase Enzymes” Das, D.; Walvoort, M. T. C.; Lukose, V.; Imperiali, B. Scientific Reports, 2016, 6, 33412. PMCID:PMC5022061.

196. “Design Principles for SuCESsFul Biosensors: Specific Fluorophore/Analyte Binding and Minimization of Fluorophore/Scaffold Interactions”. de Picciotto, S.; Dickson, P. M.; Traxlmayr, M. W.; Marques, B. S.; Socher, E.; Zhao, S.; Cheung, S.; Kiefer, J.; Griffith, L. G.; Wand, A. J.; Imperiali, B.; Wittrup, K. D. J. Mol. Biol. 2016, 428, 2228-2241. PMCID: PMC5048519.

195. “Probing Polytopic Membrane Protein - Substrate Interactions by Luminescence Resonance Energy Transfer“, Musial-Siwek, M.; Jaffee, M. B.; Imperiali, B. J. Am. Chem. Soc. 2016, 138, 3806- 3812. PMCID: PMC5480290.

194. “A Modular Approach to Phosphoglycosyl Transferase Inhibitors Inspired by Nulceoside Antibiotics”  Walvoort, M. T. C.; Lukose, V.; Imperiali, B. Chem. Eur. J. 2016, 22, 3856-3864.  PMC5506376

2015

   
193.  “Conservation and Covariance in Monotopic Phosphoglycosyltransferases Identifies the Functional Catalytic Core” Lukose, V.; Luo, L.; Kozakov, D.; Vajda, S.; Allen, K. N.; Imperiali, B. Biochemistry, 2015, 54, 7326-7234. PMCID: PMC5483379.
                                                                                                     
192. “Chemoenzymatic Assembly of Bacterial Glycoconjugates for Site-Specific Orthogonal Labeling”, Lukose, V; Whitworth, G; Guan, Z.; Imperiali, B. J. Am. Chem. Soc. 2015, 137, 12446-12449. PMCID: PMC4599313.                         

191. “Encoded Loop-Lanthanide-Binding Tags for Long-Range Distance Measurements in Proteins by NMR and EPR Spectroscopy”, Barthelmes, D.; Gränz, M.; Barthelmes, K.; Allen, K. N.; Imperiali, B.; Prisner, T.; Schwalbe, H. J. Biomol. NMR 2015, 63, 275-282.

190. “Covalent Modification Of Synthetic Hydrogels With Bioactive Proteins Via Sortase-Mediated Ligation“ Cambria, E.; Renggli, K.; Ahrens, C. C.; Cook, C. D.; Kroll, C.; Krueger, A. T.; Imperiali, B.; Griffith, L. G. Biomacromolecules, 2015, 16, 2316-2326.  PMC4613866

189. ”N-Linked Glycans are Assembled on Highly Reduced Dolichol Phosphate Carriers in the Hyperthermophilic Archaea Pyrococcus furiosus,” Chang, M. M; Imperiali, B.; Eichler, J; Guan, Z.  PLoS One 2015, 10 6 e0130482.  PMC4476749

188. ”Selective Biochemical Labeling of C. jejuni Cell-Surface Glycoconjugates” Whitworth, G.; Imperiali, B. Glycobiology 2015, 25, 756-766.  PMC25761366

187. “The Best and the Brightest: Exploiting Tryptophan-Sensitized Tb3+ Luminescence to Engineer Lanthanide-Binding Tags”  Martin, L. J.; Imperiali, B. Methods in Molecular Biology 2015, 1248, 201-220.  

2014

186. Peterson, L. B.; Imperiali, B. (2014) Real-Time and Continuous Sensors of Protein Kinase Activity Utilizing Chelation-Enhanced Fluorescence. Book Chapter in “Concepts and Case Studies in Chemical Biology”, (Edited by H. Waldmann and P. Janning) ISBN: 978-3-527-33611-1.

185. “Tailoring Chimeric Ligands for Studying and Biasing ErbB Receptor Family Interactions" Krueger, A. T.; Kroll, C.; Sanchez, E.; Griffith, L. G.; Imperiali, B. Angew. Chem. Int. Ed. 2014, 53, 2662-2666.  PMC4018821

184. “Quantification of Protein Kinase Enzymatic Activity in Unfractionated Cell Lysates Using CSox-Based Sensors“ Beck, J. R.; Peterson, L. B.; Imperiali, B.; Stains, C. I. Curr. Protoc. Chem. Biol. 2014, 6, 135-156.  PMC4174361

183. “Selective Mitogen Activated Protein Kinase Activity Sensors through the Application of Directionally-Programmable D Domain Motifs” Peterson, L. B.; Yaffe, M. B.; Imperiali, B. Biochemistry 2014, 53, 5771-5778.  PMC4165445

182. “Equilibrium and Dynamic Design Principles for Binding Molecules Engineered for Reagentless Biosensors” de Picciotto, S.; Imperiali, B.; Griffith, L. G.; Wittrup, K. D. Analytical Biochem. 2014, 460, 9-15.  PMC4104283

181. “The Renaissance of Bacillosamine and Its Derivatives: Pathway Characterization and Implications in Pathogenicity” Morrison, M. J. Imperiali, B. Biochemistry, 2014, 53, 624-638.  PMC3951908

2013

180. “Two-Photon Fluorescence Spectroscopy and Imaging of 4-Dimethylamino-naphthalimide-Peptide and Protein Conjugates” McLean, A. M.; Socher, E.; Clark, T. B.; Imperiali, B.; Goodson, T. III, J. Phys. Chem. 2013, 117, 15935-15942. PMC3938489

179. “Lipid Bilayer Nanodisc Platform for Investigating Polyprenol-Dependent Enzyme Interactions and Activities" Hartley, M. D.; Schneggenburger, P. E. Imperiali, B. Proc. Natl. Acad. Sci. USA. 2013, 110, 20863-20870. PMC3876266

178. “Biochemical Analysis and Structure Determination of Bacterial Acetyltransferases Responsible for the Biosynthesis of UDP-N,N’-Diacetylbacillosamine” Morrison, M. J., Imperiali, B., J. Biol. Chem. 2013, 288, 32248-32260.  PMC3820863.

177. “Biosynthesis of UDP-N,N’Diacetylbacillosamine in Acinetobacter baumannii: Biochemical Characterization and Correlation to Existing Pathways” Morrison, M. J.; Imperiali, B.  Arch. Biochem Biophys. 2013, 536, 72-80.  PMC3722612

176. "Biochemical Evidence for an Alternate Pathway in N-linked Glycoprotein Biosynthesis" Larkin, A.; Chang, M. M.; Whitworth, G.E.; Imperiali, B. Nature Chemical Biology, 2013, 9, 367-373.  PMC3661703

175. "Optimized Protocol for Expression and Purification of PglB the Membrane-Bound Bacterial Oligosaccharyl Transferase" Jaffee, M. B.; Imperiali, B. Protein Expression & Purification, 2013, 89, 241-250.  PMC3690457

174. "Fluorescent Amino Acids: Modular Building Blocks for the Assembly of New Tools for Chemical Biology” Krueger, A. T.; Imperiali B.  ChemBioChem, 2013, 14, 788-799.   DOI: 10.1002/cbic.201300079

173. "Caged Mono- and Divalent Ligands for Light-Assisted Disruption of PDZ Domain-Mediated Interactions” Sainlos, M.; Iskenderian-Epps, W. S.; Olivier, N. B.; Choquet, D.; Imperiali B.  J. Am. Chem. Soc. 2013, 135, 4580-4583.                        

172. "FRET-CAPTURE: A Sensitive Method for the Detection of Dynamic Protein Interactions” Socher, E.; Imperiali B. ChemBioChem 2013, 14, 53-57.  PMC3776414  

2012 

171. “Tailoring Encodable Lanthanide-Binding Tags as MRI Contrast Agents” Daughtry, K. D.; Martin, L. M.; Sarraju, A.; Imperiali, B.; Allen, K. N.  ChemBioChem 2012, 13, 2567-2574.  DOI: 10.1002/cbic.201200448          

170. "Interrogating Signaling Nodes Involved in Cellular Transformations Using Kinase Activity Probes" Stains, C. I.; Tedford, N. C.; Walkup, T. C.; Luković, E.; Goguen, B. N.; Griffith, L. G.; Lauffenburger, D. A.; Imperiali, B. Chemistry & Biology 2012, 19, 210-217.  PMC3307342

169. "At the Membrane Frontier: A Prospectus on the Remarkable Evolutionary Conservation of Polyprenols and Polyprenyl-phosphates" Hartley, M. D.; Imperiali, B. Arch. Biochem. Biophys. 2012, 517, 83-97.  PMC3253937

2011

168. "Chemical Tools for Studying Directed Cell Migration" Goguen, B. N. Imperiali, B. ACS Chemical Biology, 2011, 6, 1164-1174.  PMC3220797   

167. "Exploiting Topological Constraints to Reveal Buried Sequence Motifs in the Membrane-Bound N-Linked Oligosaccharyl Transferases” Jaffee, M. B.; Imperiali, B. Biochemistry, 2011, 50, 7557-7567.  PMC3164389

166. "Sequential Activation and Deactivation of Protein Function Using Spectrally Differentiated Caged Phosphoamino Acids" Goguen, B. N.; Aemissegger, A.; Imperiali, B. J. Am. Chem. Soc. 2011, 133, 11038-11041.  PMC3146339

165. "Genetic and Molecular Analyses Reveal an Evolutionary Trajectory for Glycan Synthesis in a Bacterial Protein Glycosylation System" Børud, B.; Viburiene, R.; Hartley, M. D.; Paulsen, B. S.; Egge-Jacobsen, W.; Imperiali, B.; Koomey, M. Proc. Natl. Acad. Sci. USA, 2011, 108, 9643-9648.  PMC3111294

164. "The Expanding Horizons of Asparagine-Linked Glycosylation" Larkin, A.; Imperiali, B. Biochemistry, 2011, 50, 4411-4426.  PMC3101296

163. "Development of a Fluorogenic Sensor for Activated Cdc42" Goguen, B. N.; Loving, G. S.; Imperiali, B. Bioorg. Med. Chem. Lett. 2011, 21, 5058-5061.  PMC3156282

162. "Biochemical Characterization of the O-linked Glycosylation Pathway in Neisseria gonorrhoeae Responsible for Biosynthesis of Pilin Glycans Containing N,N’-Diacetylbacillosamine" Hartley, M. D.; Morrison, M. J.; Aas, F. E.; Børud, B.; Koomey, M.; Imperiali, B. Biochemistry, 2011, 50, 4936-4948.  PMC3108506  

161. "Light-Triggered Myosin Activation for Probing Dynamic Cellular Processes" Goguen, B. N.; Hoffman, B. D.; Sellers, J. R.; Schwartz, M. A.; Imperiali, B. Angew. Chem. Int. Ed. 2011, 50, 5667-5670.  PMC3406609

160. "Engineering Encodable Lanthanide Binding Tags (LBTs) into Loop Regions of Proteins" Barthelmes, K.; Reynolds, A. M.; Peisach, E.; Jonker, H.; Allen, K. N.; Imperiali, B.; Schwalbe, H. J. Am. Chem. Soc. 2011, 133, 808-819.  PMC3043167

159. "Biomimetic Divalent Ligands for the Acute Disruption of AMPAR Stabilization" Sainlos, M.; Tigaret, C.; Poujol, C.; Olivier, N. B.; Bard, L.; Breillat, C.; Thiolon, K.; Choquet, D.; Imperiali, B. Nature Chemical Biology, 2011, 7, 81-91.  

158. "A p38α-Selective Chemosensor for use in Unfractionated Cell Lysates" Stains, C. I.; Luković, E.; Imperiali, B. ACS Chemical Biology, 2011, 6, 101-105.  PMC3025060

2010

157. "Perturbing the Folding Energy Landscape of the Bacterial Immunity Protein Im7 by Site-Specific N-Linked Glycosylation" Chen, M. M.; Bartlett, A. I.; Nerenberg, P. S.; Friel, C. T.; Hackenberger, C. P. R.; Stultz, C. M.; Radford, S. E.; Imperiali, B. Proc. Natl. Acad. Sci. USA, 2010, 107, 22528-22533.  PMC3012502

156. "Development of a Multicomponent Kinetcic Assay in the Early Enzymes in the Campylobacter jejuni N-Linked Glycosylation Pathway" Morrison, J. P.; Troutman, J. M.; and Imperiali, B. Bioorg. Med. Chem. 2010, 18, 8167-8171.  PMC2981441

155. "Dynamic and Specific Interaction Between Synaptic NR2-NMDA Receptor and PDZ Proteins" Bard, L.; Sainlos, M.; Cousins, S.; Mikasova, L.; Breillat, C.; Stephenson, F. A.; Imperiali, B.; Choquet, D.; Groc, L. Proc. Natl. Acad. Sci. USA 2010, 107, 19561-19566.  PMC2984211

154. "Modulation of Shank3 PDZ Domain Ligand-binding Affinity by Dimerization” Iskenderian-Epps, W. S.; Imperiali, B. ChemBioChem, 2010, 11, 1979-1984. 

153. "Structural Analysis of WbpE from Pseudomonas aeruginosa PAO1: A Nucleotide Sugar Aminotransferase Involved in O-antigen Assembly" Larkin, A.; Olivier, N. B.; Imperiali, B. Biochemistry, 2010, 49, 7227-7237.  PMC2923267

152. "Lanthanide-Tagged Proteins – An Illuminating Partnership" Allen, K. N. Imperiali, B. Current Opin. Chem. Biol. 2010, 14, 247-254

2009

151. "Monitoring Protein Kinases in Cellular Media with Highly Selective Chimeric Reporters", Lukovic, E.; Vogel Taylor, E.; Imperiali, B. Angew. Chem. Int. Ed. 2009, 48, 6828-6831.  PMC2937354

150. "Thiol-reactive Derivatives of the Solvatochromic 4-N,N-Dimethylamino-1,8-naphthalimide Fluorophore: A Highly Sensitive Toolset for the Detection of Biomolecular Interactions" Loving, G. S. Imperiali, B. Biocong. Chem. 2009, 20, 2133-2141.  PMC2783863

149. "Synthesis of Red-shifted 8-Hydroxyquinoline Derivatives Using Click Chemistry and Their Incorporation into Phosphorylation Chemosensors" González-Vera, J. A.; Luković, E.; Imperiali, B. J. Org. Chem. 2009, 74, 7309-7314.  PMC2762270

148. "Monitoring Protein Interactions and Dynamics with Solvatochromic Fluorophores" Loving, G. S.; Sainlos, M.; Imperiali, B. Trends in Biotechnol. 2009, 28, 73-83.  PMC2818466

147. “Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: Enzymes in the Wbp Pathway Responsible for O-antigen Assembly in Pseudomonas aeruginosa PAO", Larkin, A.; Imperiali, B. Biochemistry, 2009, 48, 5446-5455.  PMC2694220

146. "A General Screening Strategy for Peptide-Based Fluorogenic Ligands: Probes for Dynamic Studies of PDZ Domain-Mediated Interactions”, Sainlos, M.; Iskenderian, W. S.; Imperiali, B. J. Am. Chem. Soc. 2009, 131, 6680-6682.  PMC2828873

145. "Campylobacter jejuni PglH is a Single Active Site Processive Polymerase that Utilizes Product Inhibition to Limit Sequential Glycosyl Transfer Reactions" Troutman, J.; Imperiali, B.  Biochemistry, 2009, 48, 2807-2816.  PMC2736683

144. "A Rapid Method for Generation of Selective Sox-based Chemosensors of Ser/Thr Kinases Using Combinatorial Peptide Libraries" González-Vera, J.A.; Luković, E.; Imperiali, B. Bioorg. Med. Chem. Lett. 2009, 19, 1258-1260.  PMC2838374

143. "Native Chemical Ligation: Semisynthesis of Post-Translationally Modified Proteins and Biological Probes" Imperiali, B.: Vogel, E. M. in Protein Engineering,   Köhrer, C.; RajBhandary, U. L. Eds. Springer 2009, Chapter 3, pp 65-96.

2008

142. "A Versatile Amino Acid Analogue of the Solvatochromic Fluorophore 4-N,N-Dimethylamino-1,8-naphthalimide: A Powerful Tool for the Study of Dynamic Protein Interactions" Loving, G. S.; Imperiali, B. J. Am. Chem. Soc. 2008, 130, 13630-13638.  PMC2647014

141. "Recognition-Domain Focused (RDF) Chemosensors: Versatile and Efficient Reporters of Protein Kinase Activity" Luković, E.; González-Vera, J. A.; Imperiali, B. J. Am. Chem. Soc. 2008, 130, 12821-12827.  PMC2637182

140. "Crystal Structure and Catalytic Mechanism of PglD from Campylobacter jejuni" Olivier, N. B.; Imperiali, B. J. Biol. Chem. 2008, 283, 27937-27946.  PMC2562079.

139. "Affinity-Capture Tandem Mass Spectrometric Characterization of Polyprenyl-linked Oligosaccharides: A Novel Tool to Study Protein N-Glycosylation Pathways" Reid, C. W.; Stupak, J.; Chen, M. M.; Imperiali, B.; Li, J.; Szymanski, C. M. Analytical Chem. 2008, 80, 5468-5475.  PMC2763189

138. "Structure Determination of a Galectin-3 – Carbohydrate Complex Using Paramagnetism-based NMR Constraints" Zhuang, T.; Lee, H-S.; Imperiali, B.; Prestegard, J. H. Protein Science, 2008, 17, 1220-1231.  PMC2442008

137. "Solution Structure of Alg13: The Sugar Donor Subunit of a Yeast N-Acetylglucosamine Transferase" Wang, X.; Weldeghorghis, T.; Zhang, G.; Imperiali, B.; Prestegard, J. H. Structure, 2008, 16, 965-975.  PMC2486831

136. "Chemoenzymatic Synthesis of Polyprenyl Phosphates" Hartley, M. D.; Larkin, A.; Imperiali, B. Bioorg. Med. Chem. 2008, 16, 5149-5156.  PMC2471869

135. "Lanthanide-Binding Tags with Unnatural Amino Acids: Sensitizing Tb3+ and Eu3+ Luminescence at Longer Wavelengths" Reynolds, A. M.; Sculimbrene, B. R.; Imperiali, B. Bioconjugate Chem. 2008, 19, 588-591.

2000-2007

134. "Polyisoprene Specificity in the Campylobacter jejuni N-linked Glycosylation Pathway" Chen, M. M; Weerapana, E.; Ciepichal, E.; Stupak, J.; Reid, C. W.; Swiezewska, E.; Imperiali, B. Biochemistry, 2007, 46, 14342-14348.  PMC2585822

133."Synthesis of Anhydride Precursors of the Environment-Sensitive Fluorophores 4-DMAP and 6-DMN" Sainlos, M.; Imperiali, B. Nature Protocols, 2007, 2, 3219-3225.

132. "Tools for Investigating Peptide-Protein Interactions: Peptide Incorporation of Environment-Sensitive Fluorophores through SPPS-based ‘Building Block’ Approach" Sainlos, M.; Imperiali, B. Nature Protocols, 2007, 2, 3210-3218.

131. "Tools for Investigating Peptide-Protein Interactions: Peptide Incorporation of Environment-Sensitive Fluorophores via on Resin Derivatization" Sainlos, M.; Imperiali, B. Nature Protocols 2007, 2, 3201-3209.

130. "Double Lanthanide-Binding Tags for Macromolecular Crystallographic Structure Determination" Silvaggi, N. J.; Martin, L. J.; Schwalbe, H.; Imperiali, B.; Allen, K. N. J. Am. Chem. Soc. 2007, 129, 7114-7120.

129."Double Lanthanide-Binding Tags: Design, Photophysical Properties and NMR Applications" Martin, L. J.; Hähnke, M. J.; Nitz, M.; Wöhnert, J.; Silvaggi, N. J.; Allen, K. N.; Schwalbe, H.; Imperiali, B. J. Am. Chem. Soc. 2007, 129, 7106-7113.

128. "Caged O-Phosphorothioyl Amino Acids as Building Blocks for Fmoc-based Solid Phase Peptide Synthesis" Aemissegger, A.; Carrigan, C. N.; Imperiali, B. Tetrahedron, 2007, 63, 6185-6190.  PMC2699315

127. "From Peptide to Protein: Comparative Analysis of the Substrate Specificity of N-Linked Glycosylation in C. jejuni" Chen, M. M.; Glover, K. J.; Imperiali, B. Biochemistry, 2007, 46, 5579-5585.

126. "Fluorogenic Probes for Monitoring Peptide Binding to Class II MHC Proteins in Living Cells" Venkatraman, P.; Nguyen, T.; Sainlos, M. Bilsel, O. Calvo-Calle, Chitta, M. S. Imperiali, B.; Stern, L. J. Nature Chemical Biology 2007, 3, 222-228.  PMC3444530

125."Semisynthesis of Unnatural Amino Acid Mutants of Paxillin:  Protein Probes for Cell Migration Studies" Vogel, E. M.; Imperiali, B. Protein Science 2007, 16, 550-556.  PMC2203312

124. "In vitro biosynthesis of UDP-N,N’-diacetylbacillosamine by Enzymes of the Campylobacter jejuni General Protein Glycosylation System" Olivier, N. B.; Chen, M. M.; Behr, J. R.; Imperiali, B. Biochemistry 2006, 45, 13659-13669.  PMC2542654

123."In vitro Evidence for the Dual Function of Alg2 and Alg11: Essential Mannosyltransferases in N-linked Glycoprotein Biosynthesis" O’Reilly, M. K.; Zhang, G.; Imperiali, B. Biochemistry, 2006, 45, 9593-9603.

122. "Lanthanide Binding Tags as Luminescent Probes for Studying Protein Interactions" Sculimbrene, B. R.; Imperiali, B. J. Am. Chem. Soc. 2006, 128, 7346-7352.

121."Direct Biochemical Evidence for the Utilization of UDP-Bacillosamine by PglC, an Essential Glycosyl-1-phosphate-transferase in the C. jejuni N-linked Glycosylation Pathway" Glover, K. J.; Weerapana, E.; Chen, M. M.; Imperiali, B. Biochemistry, 2006, 45, 5343-5350.

120."Expression of N-Terminal Cys-Protein Fragments using an Intein Refolding Strategy" Hackenberger, C. P. R.; Chen, M. M.; Imperiali, B. Bioorg. Med. Chem. 2006, 14, 5043-5048.

119. "Optimal Sox-based Fluorescence Chemosensor Design for Serine/Threonine Protein Kinases" Shults, M. D.; Carrico-Moniz, D.; Imperiali, B. Analytical Biochem. 2006, 352, 198-207.

118. "Asparagine-linked Protein Glycosylation: From Eukaryotic to Prokaryotic Systems" Weerapana, E.; Imperiali, B. Glycobiology, 2006, 16, 91R-101R.

117. "Chemoenzymatic Synthesis of Glycopeptides using PglB, a Bacterial Oligosaccharyl Transferase from Campylobacter jejuni " Glover, K. J.; Weerapana, E.; Imperiali, B. Chemistry & Biology 2005, 12, 1311-1316.  PMC2519243

116."Rapid Combinatorial Screening of Peptide Libraries for the Selection of Lanthanide-Binding Tags (LBTs)" Martin, L. J.; Sculimbrene, B. R.; Nitz, M.; Imperiali, B. QSAR Comb. Sci. 2005, 10, 1149-1157.

115."Investigating Bacterial N-linked Glycosylation: Synthesis and Glycosyl Acceptor Activity of Undecaprenylpyrophosphate-linked Bacillosamine" Weerapana, E.; Glover, K. J.; Chen, M. M.; Imperiali, B. J. Am. Chem. Soc. 2005, 127, 13766-13767.  PMC1351108

114. "In vitro Assembly of the Undecaprenylpyrophosphate-Linked Heptasaccharide for Prokaryotic N-linked Glycosylation" Glover, K. J.; Weerapana, E.; Imperiali, B. Proc. Natl. Acad. Sci. USA, 2005, 102, 14255-14259.  PMC1242339

113. "Semi-synthesis of a Glycosylated Im7 Analogue for Protein Folding Studies" Hackenberger, C. P. R; Friel, C. T.; Radford, S. E.; Imperiali, B. J. Am. Chem. Soc. 2005, 127, 12882-12889.  PMC1356972

112. "Chemical Approaches for Investigating Phosphorylation in Signal Transduction Networks" Rothman, D. M.; Shults, M. D.; Imperiali, B. Trends Cell. Biol. 2005, 15, 502-510.

111. "Protein Oligomerization: How and Why" Ali, M. H.; Imperiali, B. Bioorg. Med. Chem. 2005, 13, 5013-5020.

110. "In situ Photoactivation of a Caged Phosphotyrosine Peptide Derived from Focal Adhesion Kinase Temporarily Halts Lamellar Extension of Single Migrating Tumor Cells" David Humphrey, D.; Rajfur, Z.; Vazquez, M. E.; Scheswohl, D.; Schaller, M. D.; Jacobson, K.; Imperiali, B. J. Biol. Chem. 2005, 280, 22091-22101. 

109. "The Engineering of Membrane-Permeable Peptides" Carrigan, C. N.; Imperiali, B., Analytical Biochem. 2005, 341, 290-298. 

108. "Improving Glycopeptide Synthesis: A Convenient Protocol for the Preparation of β−Glycosylamines and the Synthesis of Glycopeptides" Hackenberger, C. P. R.; O’Reilly, M. O.; Imperiali, B. J. Org. Chem. 2005, 70, 3574-3578. 

107. "A Multiplexed Homogenous Fluorescence-Based Assay for Protein Kinase Activity in Cell Lysates," Shults, M. D.; Janes, K. A.; Lauffenburger, D. A.; Imperiali, B. Nature Methods, 2005, 2, 277-284.

106."Design of a Heterospecific, Tetrameric, 21-Residue Miniprotein with Mixed α/β Structure" Ali, M. H.; Taylor, C. M.; Grigoryan, G.; Allen, K. N.; Imperiali, B.; Keating, A. E. Structure, 2005, 13, 225-234.

105. "Photophysics and Biological Applications of the Environment-Sensitive Fluorophore 6-N,N-Dimethylamino-2,3-Naphthalimide" Vázquez,  M. E.; Canosa,  J. B. B.; Imperiali, B. J. Am. Chem. Soc. 2005, 127, 1300-1306.

104. "Caged Phosphoproteins," Rothman, D. M.; Petersson, E. J.; Vázquez, M. E.; Brandt, G. S.; Dougherty, D. A.; Imperiali, B. J. Am. Chem. Soc. 2005, 127, 846-847.

103. "Heterologous Expression and Biophysical Characterization of Soluble Oligosaccharyl Transferase Subunits," Dempski, R. E. Jr.; Imperiali, B. Arch. Biochem. Biophys. 2004, 431, 63-70.

102. "A New Environment-Sensitive Fluorescent Amino Acid for Fmoc-based Solid Phase Peptide Synthesis," Vázquez, M. E.; Rothman, D. M.; Imperiali, B. Org. Biomol. Chem. 2004, 2, 1965-1966.

101. "X-Ray Structure Analysis of a Designed Oligomeric Mini-Protein Reveals a Discrete Quaternary Architecture," Ali, M. H.; Peisach, E.; Allen, K. N.; Imperiali, B. Proc. Natl Acad. Sci. USA, 2004, 101, 12183-12188.  PMC514454

100. "Caged Phosphopeptides Reveal a Temporal Role for 14-3-3 in G1 Arrest and S-Phase Checkpoint Function," Nguyen, A.; Rothman, D. M.; Stehn, J.; Imperiali, B.; Yaffe, M. B.  Nature Biotechnology, 2004, 22, 993-1000.

99. "Effects of Glycosylation on Peptide Conformation: A Synergistic Experimental and Computational Study," Bosques, C. J.; Tschampel, S. M.; Woods, R. J.; Imperiali, B. J. Am. Chem. Soc. 2004, 126, 8421-8425.  PMC1386730

98. "Structural Origin of the High Affinity of a Chemically Evolved Lanthanide Binding Peptide," Nitz, M.; Sherawat, M.; Franz, K. J.; Peisach, E.; Allen, K. N.; Imperiali, B. Angew. Chem. Int. Ed. 2004, 43, 3682-3685.

97. "Application of Photoactivation and CALI (Chromophore-Assisted Light Inactivation) Technologies to Problems in Cell Motility," Humphrey, D.; Rajfur, Z.; Imperiali, B.; Marriott, G.; Roy, P.; Jacobson, K. in Live Cell Imaging: A Laboratory Manual, Spector, D. L.; Goldman, R. D. Eds. Cold Spring Harbor Laboratory Press (2005), Chapter 10, pp 159-176.

96. "Versatile Fluorescence Probes of Protein Kinase Activity," Shults, M. D.; Imperiali, B.  J. Am. Chem. Soc. 2003, 125, 14248-14249.

95. "Protein Alignment by a Coexpressed Lanthanide-Binding Tag for the Measurement of Residual Dipolar Couplings," Wöhnert, J.; Franz, K. J.; Nitz, M.; Imperiali, B.; Schwalbe, H. S. J. Am. Chem. Soc. 2003, 125, 13338-13339.

94. "Caged Phospho-Amino Acid Building Blocks Amenable to Fmoc-based Solid Phase Peptide Synthesis," Rothman, D. M.; Vázquez, M. E.; Vogel, E. M.; Imperiali, B. J. Org. Chem. 2003, 68, 6795-6798.

93. "A Modular and Tunable Chemosensor Scaffold for Divalent Zinc," Shults, M. D.; Pearce, D. A.; Imperiali, B. J. Am. Chem. Soc. 2003, 125, 10591-10597. 

92. "Fluorescent Caged Phosphoserine Peptides as Probes to Investigate Phosphate-Dependent Protein Associations," Vázquez, M. E.; Nitz, M.; Stehn, J.; Yaffe, M. B. Imperiali, B.  J. Am. Chem. Soc.  2003, 125, 10150-10151.

91. "Photolytic Control of Peptide Self-Assembly," Bosques, C. J.; Imperiali, B.  J. Am. Chem. Soc. 2003, 125, 7530-7531.

90. "Chemistry and Biochemistry of Asparagine-Linked Protein Glycosylation," Imperiali, B.; Tai, V. W-F. in "Carbohydrate-based Drug Discovery"; Wong, C. H., ed. Wiley-VCH Verlag GmbH Publisher: Weinheim, 2003, pp 281-303. 

89. "The Interplay of Glycosylation and Disulfide Formation Influences Fibrillization in a Prion Protein Fragment," Bosques, C. J.; Imperiali, B. Proc. Natl. Acad. Sci. USA 2003, 100, 7593-7598.  PMC164631

88. "A Chemist’s Approach to Biochemical Complexity,” Aldridge, S.; Imperiali, B. Chem. Comm. 2003, 445-447.

87. "A Powerful Combinatorial Screen to Identify High-Affinity Terbium(III)-Binding Peptides," Nitz, M.; Franz, K. J.; Maglathlin, R. L.; Imperiali, B. ChemBioChem. 2003, 4, 272-276.

86. "Lanthanide-Binding Tags as Versatile Protein Coexpression Probes," Franz, K. J.; Nitz, M.; Imperiali, B. ChemBioChem. 2003, 4, 265-271.

85. "Peptides to Peptidomimetics: Towards the Design and Synthesis of Bioavailable Inhibitors of Oligosaccharyl Transferase," Weerapana, E.; Imperiali, B. Org. Biomol. Chem. 2003, 1, 93-99.

84. "Oligosaccharyl Transferase: Gatekeeper to the Secretory Pathway," Dempski, R. E. Jr.; Imperiali, B. Curr. Op. Chem. Biol. 2002, 6, 844-850.

83. "Neoglycopeptides as Inhibitors of Oligosaccharyl Transferase: Insight into Negotiating Product Inhibition," Peluso, S.; Ufret, M. de L.; O'Reilly, M. K.; Imperiali, B. Chemistry & Biology 2002, 9, 1323-1328.

82."Enantioselective Synthesis and Application of the Highly Fluorescent and Environment-Sensitive Amino Acid 6-(2-dimethylaminonaphthoyl) Alanine (DANA)," Nitz, M.; Mezo, A. R.; Ali, M. H.; Imperiali, B. Chem. Comm. 2002, 1912-1913.

81. "A General Method for the Synthesis of Caged Phosphopeptides: Tools for the Exploration of Signal Transduction Pathways," Rothman, D. M.; Vázquez, M. E.; Vogel, E. M.; Imperiali, B. Org. Lett. 2002, 4, 2865-2868.

80. "Oligomeric ββα Mini-Protein Motifs: Pivotal Role of Single Hinge Residue in Determining the Oligomeric State," McDonnell, K. A.; Imperiali, B. J. Am. Chem. Soc. 2002, 124, 428-433.

79. "Stereoselective Synthesis of β−Linked TBDMS-Protected Chitobiose-Asparagine:  A Versatile Building Block for Amyloidogenic Glycopeptides," Bosques, C. J.; Tai, V. W.-F.; Imperiali, B. Tetrahedron Lett. 2001, 42, 7207-7210.

78. "Substrate Specificity for the Glycosyl Donor of Oligosaccharyl Transferase," Tai, V. W.-F.; Imperiali, B. J. Org. Chem. 2001, 66, 6217-6228.

77. "Probing the Effect of the Outer Saccharide Residues of N-Linked Glycans on Peptide Conformation," O'Connor, S. E.; Pohlmann, J.; Imperiali, B.; Saskiawan, I.; Yamamoto, K. J. Am. Chem. Soc. 2001, 123, 6187-6188.

76. "Asparagine Surrogates for the Assembly of N-linked Glycopeptide Mimetics by Chemoselective Ligation," Peluso, S.; Imperiali, B. Tetrahedron Lett. 2001, 42, 2085-2087.

75. "Oligomerization of Uniquely Folded Mini-Protein Motifs: Development of a Homotrimeric ββα Peptide," Mezo, A. R.; Cheng, R. P.; Imperiali, B. J. Am. Chem. Soc. 2001, 123, 3885-3891.

74. "Asymmetric Synthesis of a New 8-Hydroxyquinoline Derived α-Amino Acid and its Incorporation in a Peptidyl Sensor for Divalent Zinc," Jotterand, N.; Pearce, D. A.; Imperiali, B. J. Org. Chem. 2001, 66, 3224-3228.

73."Derivatives of 8-Hydroxy-2-methyl-quinoline are Powerful Prototypes for Zinc Sensors in Biological Systems," Pearce, D. P.; Jotterand, N.; Carrico, I. S.; Imperiali, B. J. Am. Chem. Soc. 2001, 123, 5160-5161.

72. "Design of a Discretely Folded Mini-Protein Motif with Predominantly β-Structure," Ottesen, J. J.; Imperiali, B. Nature Structural Biology, 2001, 8, 535-539.

71. "Substrate Specificity of N-Acetylglucosaminyl(diphosphodolichol) N-Acetylglucosaminyl Transferase, a Key Enzyme in the Dolichol Pathway," Tai, V. W.-F.; O’Reilly, M. K.; Imperiali, B. Bioorg. Med. Chem. 2001, 9, 1133-1140.

70. “Discovery and Characterization of a Discretely Folded Homotrimeric ββα Peptide,” Mezo, A. R.; Ottesen, J. J.; Imperiali, B.  J. Am. Chem. Soc. 2001, 123, 1002-1003.

69.  "Biopolymers: Chemical & Biological Approaches for Understanding Form & Function," (editorial) Dell, A.; Famulok, M.; Imperiali, B. Curr. Opin. Chem. Biol. 2000, 4, 599-601.

68. "a-Chloroacetyl Capping of Peptides: An N-Terminal Capping Strategy Suitable for Edman Sequencing," Shogren-Knaak, M. A.; McDonnell, K. A.; Imperiali, B. Tetrahedron Lett. 2000, 41, 827-

67. "Probing the Extended Binding Determinants of Oligosaccharyl Transferase with Synthetic Inhibitors of Asparagine-Linked Glycosylation," Ufret, M. de L.; Imperiali, B. Bioorg. Med. Chem. Lett. 2000, 10, 281-284.

 

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